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Glipita 100mg Tablet 1 Strip
Glipita is prescribed to help control blood sugar levels in adults with type 2 diabetes, in combination with diet and exercise.
It can be used alone (monotherapy) or with other diabetes medications.
⚠️ Not suitable for:
- Type 1 diabetes
- Diabetic ketoacidosis (DKA)
- Patients with a history of pancreatitis (risk not established)
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✅ Description:
Sitagliptin works by inhibiting DPP-4, an enzyme that breaks down incretin hormones (GLP-1 & GIP). These hormones:
Stimulate insulin release when blood sugar is high
Suppress glucagon secretion, reducing glucose production by the liver
By preserving incretin levels, Sitagliptin enhances glucose-dependent insulin release and glucagon suppression—helping regulate blood sugar more effectively.
It selectively inhibits DPP-4 and does not affect DPP-8 or DPP-9 at therapeutic doses.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects of Glipita 100
Most common:
- Headache
- Nasopharyngitis
- Upper respiratory tract infection
- Hypoglycemia (when combined with sulfonylureas or insulin)
✔️ 💊 Dosage & Administration of Glipita 100
Standard dose: 100 mg once daily OR 50 mg twice daily
Can be taken with or without food
Dose Adjustments for Kidney Impairment:
| Renal Function | Creatinine Clearance (CrCl) | Dose |
|---|---|---|
| Mild | ≥50 mL/min | 100 mg once daily |
| Moderate | 30–50 mL/min | 50 mg once daily |
| Severe/ESRD | <30 mL/min or on dialysis | 25 mg once daily |
Pediatric Use
Not recommended for children under 18 (safety not established)
Elderly
Kidney function may decline with age → assess renal function before starting and adjust dose if needed.
✔️ Overdose Effects of Sitagliptin
Doses up to 800 mg caused minor QTc changes; no serious adverse effects were observed
- Supportive care recommended for overdose
- Hemodialysis can remove ~13.5% of the drug in 3–4 hours
(Peritoneal dialysis: unknown efficacy)
✔️ Pregnancy & Lactation
Category B: Animal studies show no harm, but human data is lacking.
Sitagliptin is found in rat milk; it is unknown if it is present in human breast milk — use cautiously in nursing mothers.
✔️ Drug Interactions
- No major interactions with: Metformin, Glyburide, Simvastatin, Rosiglitazone, Warfarin, Oral contraceptives
- Slight increase in Digoxin levels, but no dose adjustment needed
✔️ Contraindications
Known hypersensitivity to Sitagliptin (e.g., anaphylaxis, angioedema)
✔️ Precautions & Warnings
- Stop immediately if pancreatitis is suspected
- Use cautiously when combined with insulin/sulfonylureas (adjust dose to avoid hypoglycemia)
- Monitor for severe allergic reactions (e.g., Stevens-Johnson syndrome)
✔️ Storage:
- Keep below 25°C, in a dry and dark place
- Keep out of children's reach
- Do not use after expiry
- Dispense only on a registered physician’s prescription
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
