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Glipita 100mg Tablet 1 Strip
Glipita is prescribed to help control blood sugar levels in adults with type 2 diabetes, in combination with diet and exercise.
It can be used alone (monotherapy) or with other diabetes medications.
⚠️ Not suitable for:
- Type 1 diabetes
- Diabetic ketoacidosis (DKA)
- Patients with a history of pancreatitis (risk not established)
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✅ Description:
Sitagliptin works by inhibiting DPP-4, an enzyme that breaks down incretin hormones (GLP-1 & GIP). These hormones:
Stimulate insulin release when blood sugar is high
Suppress glucagon secretion, reducing glucose production by the liver
By preserving incretin levels, Sitagliptin enhances glucose-dependent insulin release and glucagon suppression—helping regulate blood sugar more effectively.
It selectively inhibits DPP-4 and does not affect DPP-8 or DPP-9 at therapeutic doses.
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✔️ Side Effects of Glipita 100
Most common:
- Headache
- Nasopharyngitis
- Upper respiratory tract infection
- Hypoglycemia (when combined with sulfonylureas or insulin)
✔️ 💊 Dosage & Administration of Glipita 100
Standard dose: 100 mg once daily OR 50 mg twice daily
Can be taken with or without food
Dose Adjustments for Kidney Impairment:
| Renal Function | Creatinine Clearance (CrCl) | Dose |
|---|---|---|
| Mild | ≥50 mL/min | 100 mg once daily |
| Moderate | 30–50 mL/min | 50 mg once daily |
| Severe/ESRD | <30 mL/min or on dialysis | 25 mg once daily |
Pediatric Use
Not recommended for children under 18 (safety not established)
Elderly
Kidney function may decline with age → assess renal function before starting and adjust dose if needed.
✔️ Overdose Effects of Sitagliptin
Doses up to 800 mg caused minor QTc changes; no serious adverse effects were observed
- Supportive care recommended for overdose
- Hemodialysis can remove ~13.5% of the drug in 3–4 hours
(Peritoneal dialysis: unknown efficacy)
✔️ Pregnancy & Lactation
Category B: Animal studies show no harm, but human data is lacking.
Sitagliptin is found in rat milk; it is unknown if it is present in human breast milk — use cautiously in nursing mothers.
✔️ Drug Interactions
- No major interactions with: Metformin, Glyburide, Simvastatin, Rosiglitazone, Warfarin, Oral contraceptives
- Slight increase in Digoxin levels, but no dose adjustment needed
✔️ Contraindications
Known hypersensitivity to Sitagliptin (e.g., anaphylaxis, angioedema)
✔️ Precautions & Warnings
- Stop immediately if pancreatitis is suspected
- Use cautiously when combined with insulin/sulfonylureas (adjust dose to avoid hypoglycemia)
- Monitor for severe allergic reactions (e.g., Stevens-Johnson syndrome)
✔️ Storage:
- Keep below 25°C, in a dry and dark place
- Keep out of children's reach
- Do not use after expiry
- Dispense only on a registered physician’s prescription
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
